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Background: Vaccines are considered as the one of the main pillars in halting and ending the presently on-going coronavirus disease (COVID-19 disease) pandemic which has spread globally since it was first detected in Wuhan, China in December 2019. In the absence of specific therapy, infection prevention practices and mass vaccination remains the mainstay in controlling the disease. Objectives: Objective of the study was to assess COVID-19 vaccination status, socio-demographic and clinical profile among healthcare workers diagnosed with COVID-19. Methodology: A cross-sectional survey from 1st March 2021 to 30th June 2021 among healthcare workers who were diagnosed with COVID-19 in a tertiary care institute of Uttarakhand, India was conducted, and universal sampling was used. Institutional Ethics Committee approved this study. Results: Total 662 healthcare workers were diagnosed with COVID-19. 429 (64.8%) of these COVID-19 diagnosed healthcare workers had received either single (129,30%) or both dose (300,70%) of COVID-19 vaccine while remaining 233 (35.2%) belonged to non-vaccinated group. History of exposure to COVID-19 positive patients was higher in vaccinated (66.4%) than in non-vaccinated group (55%) (p = 0.004). Hospitalisation was found to be higher among non-vaccinated (5.6%) than vaccinated group (2.3%) (p = 0.029). Conclusions: This study concludes that being vaccinated against COVID-19 disease provides protection against severe infection and reduces the need for hospitalization.
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OBJECTIVE: To evaluate the incidence and pattern of cardiac involvement in children post-COVID (coronavirus disease) infection in a tertiary care referral hospital in India. METHOD(S): A prospective observational study was conducted including all consecutive children with suspected MIS-C referred to the cardiology services. RESULT(S): Of the 111 children with mean (SD) age was 3.5 (3.6) years, 95.4% had cardiac involvement. Abnormalities detected were coronary vasculopathy, pericardial effusion, valvular regurgitation, ventricular dysfunction, diastolic flow reversal in aorta, pulmonary hypertension, bradycardia and intra-cardiac thrombus. The survival rate post treatment was 99%. Early and short-term follow-up data was available in 95% and 70%, respectively. Cardiac parameters improved in majority. CONCLUSION(S): Cardiac involvement post COVID-19 is often a silent entity and may be missed unless specifically evaluated for. Early echocardiography aided prompt diagnosis, triaging, and treatment, and helps in favorable outcomes.
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Since the beginning of the year in January 2020, the world witnessed a terrifying unpredictable health emergency of human life which resulted in an outbreak of a disease known as a novel coronavirus (SARS CoV-2 / COVID-19-acute respiratory disease) which was declared a pandemic by the World Health Organization (WHO). With an abrupt increase in the number of cases, a nationwide lockdown was imposed where Pharmacists served as a lifeline by supplying medicines to people across the world and their operation has made a big difference amid the global pandemic. In such difficult times, Pharmacists have helped vulnerable patients stay well and ensured their safety amidst the pandemic. Although pharmacies and drug stores play an important part in the healing process, many people have the perception that they provide a commercial or business-like service. The doctor prescribes the right medicine with the right instructions, and the pharmacist fills the prescription for a fee. In a nutshell, it's a straightforward business. With the advancement of the healthcare system, the role of the Pharmacist has become crucial in today's era which is defined by insights and discoveries that elevate the greater well-being of humans. Due to the rapid expansion, the urban concentration of health services remains a challenge in a country like India. Hence there has to be strict monitoring governance over the healthcare framework. Copyright © 2022, Anka Publishers. All rights reserved.
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BACKGROUND AND AIM: Tell me and I will forget, show me and I may remember;involve me and I will understand Confucius Simulation training is well established in improving patient care by learning from mistakes in a safe environment. During COVID pandemic, lot of junior doctor workforce were redeployed and having not worked in paediatrics was a cause of concern and need of the hour. METHOD(S): We formulated a team of enthusiastic, passionate and dedicated registrars and identified the barriers to setting up simulation for the first time in Leicester children hospital targeting specifically junior doctors. 1. Social distancing whilst working in a team. 2. Accessibility for time out from busy workload on the wards. 3. Being put on spot fear when already stressed with workload. RESULT(S): We took the support of college tutors, Senior Consultant and Nursing team to developed robust structured pathway for simulation scenarios and how to conduct them so that learning needs are achieved. This enabled registrars let the junior doctors to attend and adapt into existing teaching rota as a simulation session. We rotated to different wards and different day of the week to cover wide range of junior doctors and kept the scenarios specific for their workplace which in turn made them more relaxed and interested. CONCLUSION(S): Simulation is a great learning tool and be able to share experience and knowledge in difficult time of pandemic was a challenging but achievable. We learned and adapted changes from each simulation as coordinators which helped in running the subsequent sessions better.
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An accurate, easy, detailed, selective and fast RP-HPLC stability representative technique was developed and validated for assessment of ivermectin in tablet dosage form. The Reverse Phase High Performance Liquid Chromatographic technique was developed for routine quantification of ivermectin in laboratory prepared mixtures as well as in combined dosage forms. The chromatographic separation was accomplished with INERTSIL C-18 ODS 250x4.6mm, 5 mu m particle size column along with acetonitrile and methanol as the mobile phase at a flow rate of 1 ml/min. Quantification was completed by using a UV detector at 245 nm and the run time was 10 minutes. The retention time was found to be 4.198 min for ivermectin. The linearity was observed in the range of 1-32 mu g/ml with correlation coefficient r= 0.9798. The % RSD for intraday and interday precision was 1.352 and 1.589 respectively. The LOD and LOQ values were found to be 2.93 and 8.79, respectively. The system suitability parameters for ivermectin such as theoretical plates and tailing factor were found to be 129.949 and 2.0, respectively. Robustness was also studied and there was no significant variation in the system suitability of the analytical method by incorporating small changes in experimental parameters. The technique has been validated for linearity, precision, accuracy and other parameters as approved by ICH guidelines. The results obtained by RP- HPLC methods are found to be fast, detailed, selective and accurate. Therefore, proposed analytical method can be used for regular analysis of ivermectin in injection, tablet and other formulations.
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The Covid-19 Pandemic and lockdown has brought about various changes in the shopping behavior of the consumers. The risk, perceptions and precautions related to Covid-19 pandemic influenced the Online Consumer Shopping Behavior. A sudden growth and numerous opportunities are being created in the field of online marketing. In the current paper, the researchers tried to find out how customers responded to online shopping during the pandemic and lockdown times. The study involved 140 respondents from different areas of Pune city. The data was collected using an online survey method. The data collected was analyzed using tests like T-Test and ANOVA. The current research will give a broad guideline to the online sellers to devise strategies for selling of their products and services online. The after effects of the pandemic may be carried ahead leading to a new normal, where sellers could make the best of this opportunity of changed consumer behavior towards online shopping. © The Electrochemical Society
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Cumulatively, nearly a Hundred million COVID-19 cases and twenty-three lakhs deaths were reported till 12 February 2021. The number of deaths was so reduced when compared with the previous week on 24-30 August. COVID-19 is an academic degree acute unwellness caused by SARS-CoV-2, mainly known to attack the lungs. Most COVID-19 patients experience fever, cough, fatigue, anorexia, and shortness of breath. There is an academic degree imperative need for effective interventions presently. Activity an irregular controlled trial with a placebo arm throughout a fatal death pandemic is very troublesome. Until herd immunity develops against SARS-CoV-2, ideally through effective vaccines, the worldwide population will keep in peril. The chapter deals with immunomodulatory therapy for the clinical management of patients. © 2021 Nova Science Publishers, Inc.
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With increasing demand for large numbers of testing during COVID-19 pandemic, came alternative protocols with shortened turn-around time. We evaluated the performance of such a protocol wherein 1138 consecutive clinic attendees were enrolled;584 and 554 respectively from two independent study sites in the cities of Pune and Kolkata. Paired nasopharyngeal and oropharyngeal swabs were tested by using both reference and index methods in blinded fashion. Prior to conducting RT-PCR, swabs collected in viral transport medium (VTM) were processed for RNA extraction (reference method) and swabs collected in dry tube without VTM were incubated in Tris-EDTA-Proteinase K buffer for 30 minutes and heat inactivated at 98oC for 6 minutes (index method). Overall sensitivity and specificity of the index method were 78.9% (95% CI 71% to 86%) and 99 % (95% CI 98% to 99.6%) respectively. Agreement between the index and reference method was 96.8 % (k = 0.83, SE=0.030). The reference method exhibited enhanced detection of viral genes (E, N and RdRP) with lower Ct values compared to the index method. The index method can be used for detecting SARS-CoV-2 infection with appropriately chosen primer-probe set and heat treatment approach in pressing time;low sensitivity constrains its potential wider use. © 2021 Cambridge University Press. All rights reserved.
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The Severe acute respiratory syndrome coronavirus-2, the contamination that prompts sickness19(covid-19), has spread quickly from the initially known cases in china in December 2019 to nations round the globe. On March 10,2020, the world health organization reported that there have been 113,702 afFirmed instances of corona virus-19 round the globe, additionaly to 4,012 passing. Due to this worldwide well being emergency analysts are handling build up a corona virus immunization. Protected and compelling immuniza-tions are going to be a game changer: yet for years to return we should always wearing covers, genuinely separating and staying faraway from swarms. Being inoculated doesn’t imply that we will laugh in the face of any potential risk and put ourselves as well as other people in danger, especially in light of the very fact that it is as yet not satisfactory what proportions the antibodies can ensure against sickness also as against contamination and transmission. Vaccine for corona virus are basic devices for managing the pandemic when joined with compelling testing and existing anticipation measures. The general undertaking to form a secure and effective coronavirus vaccine is proving to be fruitful. A handful of vaccines now are authorized round the globe, may more in development. Antibodies save an excellent many lives per annum.